38. G.N. Kerestesy, K.K. Dods, C.A.L. McFeely, M.C.T. Hartman. A continuous fluorescent assay for in vitro translation compatible with non-canonical amino acids. ACS Synth. Biol. 2024, 13, 119–128.
37. C.A. McFeely, B. Shakya, C.A. Makovsky, A.K. Haney, T.A. Cropp, M.C.T. Hartman, Extensive breaking of genetic code degeneracy with non-canonical amino acids. Nat. Commun. 2023, 14, 2008.
36. H.E.O. Franco, A.V. Le, N.Y. Chang, M.C.T. Hartman, p-Chloropropynyl Phenylalanine, a Versatile Non-Canonical Amino Acid for Co-Translational Peptide Macrocyclization and Side Chain Diversification. ChemBioChem. 2023, 24, e202300020.
35. N.A. Abrigo, K.K. Dods, C.A. Makovsky, S. Lohan, K. Mitra, K.M. Newcomb, A. Le, M.C.T. Hartman. Development of a Cyclic, Cell Penetrating Peptide Compatible with In Vitro Selection Strategies. ACS Chem. Biol. 2023. 18, 746-755.
34. C.A.L. McFeely, K.K. Dods, SS Patel, M.C.T. Hartman. Expansion of the genetic code through reassignment of redundant sense codons using fully modified tRNA, Nucleic Acids Res. 2022, 50, 11374-11386.
33. H.E.O. Franco, B.T. Chaloux, M.C.T. Hartman Spontaneous, co-translational peptide macrocyclization using p-cyanoacetylene–phenylalanine, Chem. Commun. 2022, 58, 6737-6740.
32. B. Shakya, O. G. Joyner, M.C.T. Hartman. Hyperaccurate Ribosomes for Improved Genetic Code Reprogramming. ACS Synth. Biol. 2022, 11, 2193–2201.
31. M.C.T. Hartman. Non-canonical amino acid substrates of E. coli aminoacyl-tRNA synthetases. ChemBioChem. 2022, 23, e202100299.
Selected as a Very Important Paper.
Selected as a Very Important Paper.
30. K. Mitra, M.C.T. Hartman. Silicon phthalocyanines: synthesis and resurgent applications. Org. Biomol. Chem. 2021. 19, 1168-1190.
29. Hacker, D.E.; Abrigo, N.A.; Hoinka, J.; Richardson, S.L.; Przytycka, T.M.; Hartman, M.C.T. Direct, competitive comparison of linear, monocyclic, and bicyclic libraries using mRNA display. ACS Comb. Sci. 2020. 22, 306–310.
Selected as an ACS Editors Choice Article.
Selected as an ACS Editors Choice Article.
28. E.S. Iqbal, S.L. Richardson, N. Abrigo, K.K. Dods, H.E.O.Franco, H.S. Gerrish, H. Kotapatic, I.M. Morgan, D.S. Masterson, M.C.T. Hartman. A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display. Chem. Commun. 2019. 55, 8959-8962.
Link.
27. P.S. Dupart, K. Mitra, C.E. Lyons, M.C.T. Hartman. Photo-controlled delivery of a potent analogue of doxorubicin. Chem. Commun. 2019, 55, 5607-5610.
26. K. Mitra, M. Samso, C.E. Lyons, M.C.T. Hartman. Hyaluronic acid grafted nanoparticles of aplatinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light. J. Mat. Chem. B. 2018, 6, 7373-7377.
hartman_jmatchemb_2018.pdf | |
File Size: | 2297 kb |
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25. S.L. Richardson, K.K. Dods, N.A. Abrigo, E.S. Iqbal, M.C.T. Hartman. In vitro genetic code reprogramming and expansion to study protein function and discover macrocyclic peptide ligands. Curr. Opin. Chem. Biol. 2018, 46, 172-179.
hartman_curropinchembiol_2018.pdf | |
File Size: | 1491 kb |
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24. K. Mitra, C.E. Lyons, M.C.T. Hartman*. A Novel Platinum(II) Complex of Heptamethine Cyanine for Photo‐Enhanced Cytotoxicity and Cellular Imaging in Near‐IR Light. Angew. Chem. Int. Ed. 2018, 57, 10263-10267.
23. E.S. Iqbal, M.C.T Hartman*. News and Views: Shaping Molecular Diversity. Nature Chemistry. 2018.
22. E.S. Iqbal, K.S. Dodd, M.C.T. Hartman*. Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase. Org. Biomol. Chem. 2018, 16, 1073-1078.
hartman_orgbiomolchem_2018.pdf | |
File Size: | 1285 kb |
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21. C.M. Ring, E.S. Iqbal, D.E. Hacker, M.C.T. Hartman*. T.A. Cropp*. Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purification. Org. Biomol. Chem. 2017, 15, 4536-4539.
hartman_orgbiomolchem_2017.pdf | |
File Size: | 757 kb |
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20. D.E. Hacker, J. Hoinka, E.S. Iqbal, T.M. Przytycka, M.C.T. Hartman* Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display. ACS Chem. Biol. 2017, 12, 795..
19. M.M. Dcona, J.E. Sheldon, D. Mitra, M.C.T. Hartman*. Light induced drug release from a folic acid-drug conjugate. Bioorg. Med. Chem. Lett. 2017, In press.
hartman_bioorgmedchemlett_2017.pdf | |
File Size: | 791 kb |
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18. M. Almohaini, S.L. Chalasani, D. Bafail, K. Akopiants, T. Zhou, S.M. Yannone, D.A. Ramsden, M.C.T. Hartman, L.F. Povirk*. Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair. DNA Repair. 2016, 41, 16-26.
hartman_dnarepair_2016.pdf | |
File Size: | 3690 kb |
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17. J.E. Sheldon, M.M. Dcona, C.E. Lyons, J.C. Hackett, M.C.T. Hartman*. Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog. Org. Biomol. Chem. 2016,14, 40-49.
hartman_orgbiomolchem_2015.pdf | |
File Size: | 2922 kb |
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16. M.M. Dcona, Q. Yu, J.A. Capobianco*, M.C.T. Hartman*. Near infrared light mediated release of doxorubicin using upconversion nanoparticles. Chem. Commun. 2015,18, 8477-8479.
hartman_chemcommun_2015.pdf | |
File Size: | 2935 kb |
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15. E.R. White, L. Sun, Z. Ma, J.M. Beckta, B.A. Danzig, D.E. Hacker, M. Huie, D.C. Williams, R.A. Edwards, K. Valerie, J.N.M. Glover, M.C.T. Hartman*. A peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domain. ACS Chem. Biol. 2015, 10, 1198-1208.
LINK
LINK
14. G.K. Dewkar, G. Sundaresan, N. Lamichhane, J. Hirsch, C. Thadigiri, T. Collier, M.C.T. Hartman, G. Vaidyanthan, J. Zweit*. Microfluidic radiosynthesis and biodistribution of [18F] 2-(5-fluoro-pentyl)-2-methyl malonic acid. J. Labelled Cmpd. Rad. 2013, 56, 289-294.
hartman_jradcmpd_2013.pdf | |
File Size: | 450 kb |
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13. E.R. White, T. Reed, Z. Ma, M.C.T. Hartman*. Replacing amino acids in translation: expanding chemical diversity with non-natural variants. Methods, 2013, 60, 70-74
hartman_methods_2013.pdf | |
File Size: | 448 kb |
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12. M.C.T. Hartman* and M.M. Dcona. A new, highly water-soluble, fluorescent turn-on chemodosimeter for direct measurement of hydrogen sulfide in biological fluids. Analyst 2012, 137, 4910-4912.
hartman_analyst_2012.pdf | |
File Size: | 339 kb |
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11. Y.V.Guillen Schlippe, M.C.T. Hartman, K. Josephson, J.W. Szostak. In vitro selection of highly modified cyclic peptides that act as tight-binding inhibitors. J. Am. Chem. Soc. 2012, 134, 10469-10477.
hartman_jacs_2012.pdf | |
File Size: | 2042 kb |
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10. M.M. Dcona, D. Mitra, R.W. Goehe, D.A. Gewirtz, D.A. Lebman, M.C.T. Hartman. Photocaged Permeability: A new strategy for controlled drug release. Chem. Commun. 2012, 16, 4755-4757.
hartman_chemcommun_2012.pdf | |
File Size: | 1259 kb |
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9. S.M. Dever, E.R. White, M.C.T. Hartman, K. Valerie. BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies. Cell Cycle, 2012, 11, 687-694. PMC3318103.
hartman_cellcycle_2012.pdf | |
File Size: | 1239 kb |
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dewkar_hartman_orglett_2009-peptide-cyclization.pdf | |
File Size: | 375 kb |
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Previous Publications
7. A.O. Subtelny, M.C.T. Hartman, J. W. Szostak, Optimal Codon Choice can Improve the Efficiency and Fidelity of N-Methyl Amino Acid Incorporation into Peptides by In Vitro Translation. Angew. Chem. Int. Ed., 2011, 50, 3164-3167.
6. A.O. Subtelny, M.C.T. Hartman, J. W. Szostak, Ribosomal Synthesis of N-Methyl Peptides. J. Am. Chem. Soc. 2008, 130, 6131-6136. PMCID: PMC2728122.
5. M.C.T. Hartman, K. Josephson, C-W. Lin, J. W. Szostak, An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides. PLoS ONE 2007, 2, e972. PMCID: PMC1989143.
4. M.C.T. Hartman, S. Jiang, J.S. Rush, C.J. Waechter, J.K. Coward, Glycosyltransferase Mechanisms: Impact of a 5-Fluoro Substituent in Acceptor and Donor Substrates on Catalysis Biochemistry 2007, 46, 11630-11638. PMCID: PMC2556460.
3. M.C.T. Hartman, K. Josephson, and J.W. Szostak, Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 4356-4361. PMCID: PMC1450175
2. K. Josephson, M.C.T. Hartman, and J.W. Szostak, Ribosomal Synthesis of Unnatural Peptides. J. Am. Chem. Soc. 2005, 127, 11727-11735.
1. M.C.T. Hartman and J.K. Coward, Synthesis of 5-Fluoro N-Acetylglucosamine Glycosides and Pyrophosphates via Epoxide Fluoridolysis: Versatile Reagents for the Study of Glycoconjugate Biochemistry. J. Am. Chem. Soc. 2002, 124, 10036-10053.
7. A.O. Subtelny, M.C.T. Hartman, J. W. Szostak, Optimal Codon Choice can Improve the Efficiency and Fidelity of N-Methyl Amino Acid Incorporation into Peptides by In Vitro Translation. Angew. Chem. Int. Ed., 2011, 50, 3164-3167.
6. A.O. Subtelny, M.C.T. Hartman, J. W. Szostak, Ribosomal Synthesis of N-Methyl Peptides. J. Am. Chem. Soc. 2008, 130, 6131-6136. PMCID: PMC2728122.
5. M.C.T. Hartman, K. Josephson, C-W. Lin, J. W. Szostak, An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides. PLoS ONE 2007, 2, e972. PMCID: PMC1989143.
4. M.C.T. Hartman, S. Jiang, J.S. Rush, C.J. Waechter, J.K. Coward, Glycosyltransferase Mechanisms: Impact of a 5-Fluoro Substituent in Acceptor and Donor Substrates on Catalysis Biochemistry 2007, 46, 11630-11638. PMCID: PMC2556460.
3. M.C.T. Hartman, K. Josephson, and J.W. Szostak, Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 4356-4361. PMCID: PMC1450175
2. K. Josephson, M.C.T. Hartman, and J.W. Szostak, Ribosomal Synthesis of Unnatural Peptides. J. Am. Chem. Soc. 2005, 127, 11727-11735.
1. M.C.T. Hartman and J.K. Coward, Synthesis of 5-Fluoro N-Acetylglucosamine Glycosides and Pyrophosphates via Epoxide Fluoridolysis: Versatile Reagents for the Study of Glycoconjugate Biochemistry. J. Am. Chem. Soc. 2002, 124, 10036-10053.